Abstract Surface plasmon resonance (SPR)
nanosensors based on metallic nanohole arrays have been widely reported
to detect binding interactions in biological specimens. A simple and
effective method for constructing nanoscale arrays is essential for the
development of SPR nanosensors. In this work, we report a one-step
method to fabricate nanohole arrays by thermal nanoimprinting in the
matrix of IPS (Intermediate Polymer Stamp). No additional etching
process or supporting substrate is required. The preparation process is
simple, time-saving and compatible for roll-to-roll process, potentially
allowing mass production. Moreover, the nanohole arrays were integrated
into detection platform as SPR sensors to investigate different types
of biological binding interactions. The results demonstrate that our
one-step method can be used to efficiently fabricate large-area and
uniform nanohole arrays for biochemical sensing. DOI: https://doi.org/10.1007/s11427-017-9270-x
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