Abstract Innovative nanoparticles hold promising
potential for disease therapy as drug delivery systems. For
brain‐disease therapy, a drug delivery system that can sustainably
control drug‐release and monitor fluorescence of the drug cargos is
highly desirable. In this study, a light‐traceable and intracellular
microenvironment‐responsive drug delivery system was developed based on
the combination of glutathione‐responsive autoflurescent nanogel,
dendrimer‐like mesoporous silica nanoparticles, and gold nanoparticles.
The resulting hybrid nanoparticles represent a new class of delivery
system that can efficiently load, transport, and control
multistage‐release of sulfydryl‐containing drugs into neurons, with
light‐traceable monitoring for future brain‐disease therapy. Multifunctional.pdf |